In: Ferri's Clinical Advisor 2019. https://www.niddk.nih.gov/health-information/endocrine-diseases/cushings-syndrome. "The concept and epidemiology of dhat syndrome". AllScripts EPSi. In some people, the cause of Cushing syndrome is excess cortisol secretion that doesn't depend on stimulation from ACTH and is associated with disorders of the adrenal glands. If your symptoms are more severe, you may need medication to regulate the levels of dopamine and iron in your body. Some people have the symptoms of restless legs syndrome occasionally, while others have them every day. In China, various names such as (Shen K'uei), Sri Lanka (Prameha) and other parts of South East Asia (Jiryan) symptoms and conditions are similar to dhatus. The main symptom of restless legs syndrome is an overwhelming urge to move your legs. The disorders of Dhatus have been elucidated in the Charaka Samhita, which describes a disorder called Shukrameha (शुक्रमेह) in which there is a passage of semen in the urine. Journal of Clinical Endocrinology and Metabolism. Dhat syndrome (Sanskrit: धातु दोष, IAST: Dhātu doṣa) is a condition found in the cultures of South Asia (including Pakistan, India, Bangladesh, Nepal, and Sri Lanka) in which male patients report that they suffer from premature ejaculation or impotence, and believe that they are passing semen in their urine. [8], Some doctors believe dhat syndrome to be either a culture-bound presentation of clinical depression, as a somatized set of symptoms, or a result of Western doctors' misinterpretation of patients' descriptions of their condition.[9][10]. Pada sindrom kompartemen akut, gejalanya bisa muncul beberapa jam setelah cedera dan memburuk dengan cepat. Page last reviewed: 6 August 2018 It's also possible to develop Cushing syndrome from injectable corticosteroids — for example, repeated injections for joint pain, bursitis and back pain. At other times, marked feelings of guilt associated with what the patient assumes is "excessive" masturbation are noted. A., Avasthir., O. P., Jhirwai. The endocrine system includes the pituitary gland, thyroid gland, parathyroid glands, adrenal glands, pancreas, ovaries (in females) and testicles (in males). Some neurologists (specialists in treating conditions that affect the nervous system) believe the symptoms of restless legs syndrome may have something to do with how the body handles a chemical called dopamine. At other times counseling, anti-anxiety and antidepressant medications have been shown to be of use. Without treatment, complications of Cushing syndrome may include: Mayo Clinic does not endorse companies or products. Make a donation. Nieman LK. But if the cause is unknown, the symptoms can sometimes get worse with time and severely affect the person's life. https://www.uptodate.com/contents/search. This deletion results in the poor development of several body systems. Washington, D.C.: American Psychiatric Association. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. They may be able to put you in touch with other people in your area affected by the condition. In: Endocrinology: Adult and Pediatric. A primary adrenal gland disease. Others[who?] https://labtestsonline.org/conditions/cushing-syndrome. Diagnostic and statistical manual of mental disorders (DSM-IV-TR) (4th ed., text revision). [2] The International Classification of diseases ICD-10 classifies Dhat syndrome as both a neurotic disorder (code F48.8) and a culture-specific disorder (Annexe 2) caused by "undue concern about the debilitating effects of the passage of semen". In some cases, restless legs syndrome is caused by an underlying health condition, such as iron deficiency anaemia or kidney failure. This is known as idiopathic or primary restless legs syndrome, and it can run in families. Dopamine is involved in controlling muscle movement and may be responsible for the involuntary leg movements associated with restless legs syndrome. Most of them come with the complaints of "drops" and become extremely anxious about it and see it as loss of "male power". The condition may also be due to your body's own overproduction of cortisol (endogenous Cushing syndrome). The condition can also occur when your body makes too much cortisol on its own. Accessed Jan. 21, 2019. The symptoms can vary from mild to severe. As Guillain-Barre syndrome progresses, muscle weakness can evolve into paralysis. https://www.aans.org/Patients/Neurosurgical-Conditions-and-Treatments/Cushings-Disease. Accessed Jan. 21, 2019. Philadelphia, Pa.: Elsevier; 2019. https://www.clinicalkey.com. Lapisan tersebut dikenal dengan membran mukosa di dunia kedokteran. Inhaled steroid medicines (taken for asthma) and steroid skin creams (used for skin disorders such as eczema) are generally less likely to cause Cushing syndrome than are oral corticosteroids. Restless legs syndrome is not life threatening, but severe cases can disrupt sleep (causing insomnia) and trigger anxiety and depression. The earlier treatment begins, the better your chances for recovery. Chlamydia infection might also be related to it because of similar symptoms in case of infection of the urethra (urethritis), which is usually symptomatic, causing a white discharge from the penis with or without pain on urinating (dysuria). Mayo Clinic, Rochester, Minn. Feb. 2, 2019. It may also be used to prevent your body from rejecting a transplanted organ. Jameson JL, et al., eds. Next review due: 6 August 2021. https://www.uptodate.com/contents/search. American Association of Neurological Surgeons. 7th ed. The sensation is often worse in the evening or at night. Some people have the symptoms of restless legs syndrome occasionally, while others have them every day. All rights reserved. Left untreated, Cushing syndrome can result in exaggerated facial roundness, weight gain around the midsection and upper back, thinning of your arms and legs, easy bruising and stretch marks. Males sometimes report a subjective feeling that their penises have shortened. Epidemiology and clinical manifestations of Cushing's syndrome. Mild cases of restless legs syndrome that are not linked to an underlying health condition may not require any treatment, other than making a few lifestyle changes. However, when the level of cortisol is too high in your body, you may develop Cushing syndrome. Philadelphia, Pa.: Saunders Elsevier; 2016. https://www.clinicalkey.com. Sindrom kompartemen bisa menyerang tangan, lengan, bokong, tungkai, dan kaki. Mayo Clinic, Rochester, Minn. Sept. 12, 2018. [7] Literature describing semen as a vital constituent of the human body dates back to 1500 BC. This is known as secondary restless legs syndrome. Cushing syndrome can develop from a cause outside of your body (exogenous Cushing syndrome). Dhat is thought to be a culture-bound syndrome similar to jiryan (South-East Asia), prameha (Sri Lanka), and shen-k'uei (China). Cushing syndrome can also result in high blood pressure, bone loss and, on occasion, type 2 diabetes. Nieman LK, et al. Cushing syndrome, sometimes called hypercortisolism, may be caused by the use of oral corticosteroid medication. Ferri FF. Find out more about the causes of restless legs syndrome. 2015;100:2807. DiGeorge syndrome, more accurately known by a broader term — 22q11.2 deletion syndrome — is a disorder caused when a small part of chromosome 22 is missing. If restless legs syndrome is caused by iron deficiency anaemia, iron supplements may be all that's needed to treat the symptoms. These medications, such as prednisone, have the same effect in the body as does cortisol produced by your body. Occasionally, the arms are affected, too. The symptoms of restless legs syndrome will usually disappear if it's possible to address an underlying cause. Treatment of Cushing's syndrome: An Endocrine Society clinical practice guideline. Morrow ES. The signs and symptoms of Cushing syndrome can vary depending on the levels of excess cortisol. Ruterbusch, K. (2012, July 20) "Dhat Syndrome in the Indian Subcontinent", Retrieved March 29, 2013, from anthropology.msu.edu. But, in some individuals, these medications may cause Cushing syndrome, especially if taken in high doses. Treatments for Cushing syndrome can return your body's cortisol production to normal and noticeably improve your symptoms. Contact your doctor if you have symptoms that suggest Cushing syndrome, especially if you're taking corticosteroid medication to treat a condition, such as asthma, arthritis or inflammatory bowel disease. For example, cortisol helps regulate your blood pressure, reduces inflammation, and keeps your heart and blood vessels functioning normally. It's also more common in middle age, although the symptoms can develop at any age, including childhood. In about 10% of people with the disorder, symptoms begin in the arms or face. The condition has no known organic cause. Accessed Jan. 22, 2019. Cushing syndrome can also result in high blood pressure, bone loss and, on occasion, type 2 diabetes. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Indian doctor Narendra Wig coined the term Dhat syndrome in 1960 and described it as being characterized by vague psychosomatic symptoms of fatigue, weakness, anxiety, loss of appetite, guilt, and sexual dysfunction, attributed by the patient to loss of semen in nocturnal emission, through urine or masturbation. A single copy of these materials may be reprinted for noncommercial personal use only. Too much cortisol can produce some of the hallmark signs of Cushing syndrome — a fatty hump between your shoulders, a rounded face, and pink or purple stretch marks on your skin. Guillain-Barre syndrome often begins with tingling and weakness starting in your feet and legs and spreading to your upper body and arms. Cushing's syndrome and disease. The Pituitary Society. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). [5], Dhat syndrome has been reported throughout South Asia in several communities, including "among Hindus in subcontinent, Sikhs in Punjab, Buddhists in Sri Lanka and Muslims in Pakistan. American Psychiatric Association. Nippoldt TB (expert opinion). It can also cause an unpleasant crawling or creeping sensation in the feet, calves and thighs. It is very common in Nepali culture as well. There's also a link between restless legs syndrome and pregnancy. Weight gain and fatty tissue deposits, particularly around the midsection and upper back, in the face (moon face), and between the shoulders (buffalo hump), Pink or purple stretch marks (striae) on the skin of the abdomen, thighs, breasts and arms, Thinning, fragile skin that bruises easily, Slow healing of cuts, insect bites and infections, Thicker or more visible body and facial hair (hirsutism), Bone loss, leading to fractures over time, Bone loss (osteoporosis), which can result in unusual bone fractures, such as rib fractures and fractures of the bones in the feet. In such cases, restless legs syndrome usually disappears after the woman has given birth. Narendra Wig, "Problems of Mental Health in India", "The Concept and Epidemiology of Dhat Syndrome", "Dhat syndrome in relation to demographic characteristics", "Culture-bound syndromes: the story of dhat syndrome", Reproductive endocrinology and infertility, Bachelor of Medicine, Bachelor of Surgery, https://en.wikipedia.org/w/index.php?title=Dhat_syndrome&oldid=964532953, Neurotic, stress-related and somatoform disorders, All articles with specifically marked weasel-worded phrases, Articles with specifically marked weasel-worded phrases from September 2015, Creative Commons Attribution-ShareAlike License, This page was last edited on 26 June 2020, at 02:18. The most common of these disorders is a noncancerous tumor of the adrenal cortex, called an adrenal adenoma. The symptoms can vary from mild to severe. Accessed Jan. 21, 2019. Because the doses required to treat these conditions are often higher than the amount of cortisol your body normally needs each day, side effects from excess cortisol can occur. Close menu. [4], Cognitive behavioral therapy is the mainstay of treatment. Dhat syndrome (Sanskrit: धातु दोष, IAST: Dhātu doṣa) is a condition found in the cultures of South Asia (including Pakistan, India, Bangladesh, Nepal, and Sri Lanka) in which male patients report that they suffer from premature ejaculation or impotence, and believe that they are passing semen in their urine. (2000). Often the patient describes the loss of a whitish fluid while passing urine. It also regulates the way you convert (metabolize) proteins, carbohydrates and fats in your diet into usable energy. Causes and pathophysiology of Cushing's syndrome. Oral corticosteroids may be necessary to treat inflammatory diseases, such as rheumatoid arthritis, lupus and asthma. Occasionally, benign, nodular enlargement of both adrenal glands can result in Cushing syndrome. Excess levels of the hormone cortisol are responsible for Cushing syndrome. [3] Dhat syndrome might be related to other post-orgasmic diseases, such as post-coital tristesse (PCT), postorgasmic illness syndrome (POIS), and sexual headache. See our safe care and visitor guidelines, plus trusted coronavirus information. Lynch syndrome, often called hereditary nonpolyposis colorectal cancer (HNPCC), is an inherited disorder that increases the risk of many types of cancer, particularly cancers of the colon (large intestine) and rectum, which are collectively referred to as colorectal cancer. The discharge of this "vital fluid", either through sex or masturbation, is associated with marked feelings of anxiety and dysphoria. Cortisol helps your body respond to stress. Cushing's syndrome/disease. Premature ejaculation and impotence are commonly seen. Nieman LK. (2005). Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. These symptoms are usually associated with an anxious and dysphoric mood state. This content does not have an Arabic version. https://pituitarysociety.org/patient-education/pituitary-disorders/cushings/what-are-cushings-disease-and-cushings-syndrome. But women are twice as likely to develop restless legs syndrome as men. Cushing's syndrome. Cushing's syndrome. Young males are most often affected, though similar symptoms have been reported in females with excessive vaginal discharge or leucorrhea, which is also considered a "vital fluid". Cortisol, which is produced in the adrenal glands, plays a variety of roles in your body. Cushing's syndrome. [1] The condition has no known organic cause.[2]. This may occur from excess production by one or both adrenal glands, or overproduction of the adrenocorticotropic hormone (ACTH), which normally regulates cortisol production. Cushing's disease and syndrome. Mayo Clinic is a not-for-profit organization. Accessed Jan. 21, 2019. Pages 897-903. About 1 in 5 pregnant women will experience symptoms in the last 3 months of their pregnancy, although it's not clear exactly why this is. Restless legs syndrome is also associated with involuntary jerking of the legs and arms, known as periodic limb movements in sleep (PLMS). Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter — Digital Edition, FREE book offer – Mayo Clinic Health Letter. This content does not have an English version. This site complies with the HONcode standard for trustworthy health information: verify here. Restless legs syndrome, also known as Willis-Ekbom disease, is a common condition of the nervous system that causes an overwhelming irresistible urge to move the legs. Menu Accessed Jan. 21, 2019. In the majority of cases, there's no obvious cause of restless legs syndrome. In traditional Hindu spirituality, semen is described as a "vital fluid". Restless legs syndrome is also associated with involuntary jerking of the legs and arms, known as periodic limb movements in sleep (PLMS). Treatments for Cushing syndrome can return your body's cortisol production to normal and noticeably improve your symptoms. In severe cases, restless legs syndrome can be very distressing and disrupt a person's daily activities. Namun pada sebagian besar kasus, sindrom kompartemen paling sering terjadi di bagian lutut ke bawah. Other somatic symptoms like weakness, easy fatiguability, palpitations, insomnia, low mood, guilt and anxiety are often present. Cushing syndrome occurs when your body is exposed to high levels of the hormone cortisol for a long time. Many doctors view dhat as a folk diagnostic term used in South Asia to refer to anxiety and hypochondriacal concerns associated with the discharge of semen, with discoloration of the urine, and feelings of weakness and exhaustion. Accessed Jan. 22, 2019. Restless legs syndrome is a common condition that can affect anyone at any point in their life. Accessed Jan. 21, 2019. The earlier treatment begins, the better your chances for recovery. One example is taking oral corticosteroid medications in high doses over an extended period of time. "[6], The term Dhat gets its origin from the Sanskrit word Dhatu (धातु), which, according to the Sushruta Samhita, means "elixir that constitutes the body". see it as a distinct clinical entity which is less culture-bound than these critics assert, and describe it as one form of a syndrome of "semen-loss anxiety" which also occurs in other Eastern cultures as jiryan and shen-k'uei, as well as in Western cultures. Advertising revenue supports our not-for-profit mission. It is often related with obsessive ruminations and somatoform symptoms. Sindrom Stevens-Johnson adalah kelainan serius pada kulit, serta lapisan bola mata, dalam mulut, dubur, dan alat kelamin. The charity Restless Leg Syndrome UK provides information and support for people affected by restless legs syndrome. Cancerous tumors of the adrenal cortex (adrenocortical carcinomas) are rare, but they can cause Cushing syndrome as well. Lab Tests Online. National Institute of Diabetes and Digestive and Kidney Diseases. Gejalanya bisa muncul tiba-tiba (akut) atau bertahap (kronis).
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